الفهرس | Only 14 pages are availabe for public view |
Abstract A cutaneous scar is defined as dermal fibrous replacement tissue, that results from a wound healed by resolution rather than regeneration. Pathological scars are thought to be caused by disordered regulation of wound cellularity and collagen synthesis. Once the scar is formed it undergoes several distinct macro- and microscopic changes during thematuration process and is complete on average after 1 year. Cutaneous scars include hypertrophic and keloid scars, atrophic scars, and striae distensae .Hypertrophic and keloid scars are both pathological scars and are forms of excessive dermal fibrosis. They are both characterised by increasedvascularity, high mesenchymal density, inflammatory cellinfiltration, and a thickened epidermis. Although both hypertrophic scars and keloids are clinically indurated, they differ in several clinical and histologicaspects. Clinically, hypertrophic scars are generally white to pink scars that remain within the borders of theoriginal wound and often flatten over several years. In contrast, keloids are usually deep red to purple in color, extend beyond the original wound. Once present, they do not usually regress spontaneously. |