الفهرس 
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Abstract
The present thesis is devoted for developing new methods for the analysis of some drugs used for treatment of cardiovascular diseases, namely: either in pure form, in pharmaceutical preparations or in human plasma , namely: Ezetimibe (EZT), atorvastatin calcium (ATR), losartan potassium (LOS), rosuvastatin calcium (ROSU), furosemide (FURO), torsemide (TSM). Different analytical techniques were applied for determination of the studied compounds. The thesis comprises five main parts: Part I: Included a general introduction about cardiovascular diseases drugs, their classification, and their pharmacological actions. Part II: This part involved the development of Simultaneous RP-HPLC method for determination of Ezetimibe and Atorvastatin calcium in pharmaceutical dosage forms and human plasma. Part III: In this part a first derivative synchronous spectrofluorimetric method was developped for estimation of losartan potassium and atorvastatin calcium in pure form and tablets. Part IV: A validated synchronous spectrofluorimetric method was developed for estimation of ezetimibe and rosuvastatin calcium in bulk and pharmaceutical tablets. Part V: In this part two analytical methods including spectrophotometric and spectrofluorimetric methods were developed for determination of furosemide and torsemide in pure form and pharmaceutical formulations using 1, 10 phenanthroline-Fe III reagent.