الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
T1D is an autoimmune disease. It can be associated with other autoimmune disorders that may influence the control of diabetes by disruption the function of respective organs. The prevalence of positive TAA in children with Type-1 diabetes varies considerably between 3 and 50% in different countries, and the clinical significance of these antibodies remains controversial. Moreover, there has been no consensus on screening for autoimmune thyroiditis in patients with Type-1 diabetes The aim of this study was to determine the incidence of thyroid auto-antibodies in T1D subjects, without any history of thyroid disease, anti-TPO antibodies, anti-thyroglobulin antibodies in T1D subjects. This study included 150 subjects who were divided into 2 groups; group1 that included 100 patients with type1 DM and group2 that included 50 normal healthy subjects (control group). The cases were subjected to full history taking (including demographic data and history of the current disease) and full clinical examination (general examination and local thyroid examination). Laboratory investigations were done including Fasting blood glucose, post prandial blood glucose(PPBG), glycosylated hemoglobin (A1c), anti-TPO antibodies, anti-thyroglobulin antibodies (TG), serum TSH and free T3, T4 (in some selected cases). Radiological investigations were in the form of US of the thyroid gland in cases with elevated serum anti-thyroperoxidase antibodies and anti-thyroglobulin antibodies. The results of this study showed that: 1. No statistically significant difference in the basic demographic criteria between the cases and control groups. 2. The level of thyroperoxidase antibodies and thyroglobulin antibodies was statistically significant higher in the cases group as compared with the control group. 3. No statistically significant difference in the demographic and laboratory parameters between male and female cases with diabetes. 4. No statistically significant difference in the demographic and laboratory parameters between diabetic cases from urban and rural areas except for AIC that was statistically significant higher in cases from rural areas. 5. No statistically significant difference in the demographic and laboratory parameters between diabetic cases according to the age group except for thyroglobulin antibodies that was significantly higher in the cases ≤ 10 years. 6. No statistically significant difference in the demographic and laboratory parameters between controlled and the uncontrolled diabetic cases except for thyroglobulin antibodies that was significantly higher in the uncontrolled cases. 7. There were 10 diabetic cases with positive titer for anti thyroperoxidase antibodies and 3 cases with positive titer for anti-thyroglobulin antibodies. 8. There was a statistically significant positive correlation between thyroperoxidase antibodies levels with age, height and duration of DM. 9. There was a statistically significant positive correlation between Thyroglobulin antibodies levels with age and height.