الفهرس 
In vitro fertilization and intra cytoplasmic sperm injectionOnly 14 pages are availabe for public view
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Abstract
C-reactive protein (CRP) is an acute phase protein,
produced by the liver. Its levels rise dramatically in the
presence of infection or trauma. Small increases in serum
CRP levels are believed to indicate low-grade inflammation.
The Concentration of CRP, with a molecular weight of
110, 000-120, 000 KD, increases 1000 times after invasion
and tissue damage. It activates complement and can attach to
activated lymphocytes, invasive organisms, and damaged
tissues. CRP can act as a nonspecific opsonin to increase
phagocytosis, removing cells and damaged, dead or dying
organisms, reinforce innate immunity, and protection against
tissue injury. Therefore, CRP by increasing the renovation
speed, results in healing of damaged tissues.
As ovulation is considered to be an inflammatory
process, the association between CRP levels and assisted
reproductive technique (ART) cycles has been investigated
by several studies.
Controlled hyperstimulation of the ovary and especially
puncture of the ovaries in in-vitro fertilization (IVF) or
intracytoplasmic sperm injection (ICSI) cycles is probably
associated with changes in CRP concentrations. these
changes may affect the success rate of IVF/ICSI,
implantation, and pregnancy, also administration of human
chorionic gonadotropin (HCG) regardless of the response
rate of the ovaries, causes activation of endothelial cells and
neutrophils.
A prospective cohort study that was conducted in Ain Shams University Maternity Hospital, Infertility Clinic
during period time from September 2018 to September 2020.
A total of 100 infertile women who were candidate for
IVF/ICSI, over a period of 2 years, beginning in September
2018, were recruited to the study after they met the inclusion
and exclusion criteria. The participants gave written
informed consent and approval for the ethical aspects of the
study.
This study showed no statistically significant
differences according to clinical pregnancy regarding the
sociodemographic data as BMI, duration of infertility and
type of infertility and regarding Oocyte retrieval and embryo
transfer, also no significant differences according to clinical
pregnancy regarding CRP at baseline and at Oocyte pickup
as well as CRP change at oocyte pickup. But age was
significantly lower in cases with clinical pregnancy and CRP
at embryo transfer and CRP change at embryo transfer were
significantly higher in cases with positive pregnancy.
Finally, we concluded that C-reactive protein (CRP) is a
sensitive marker in inflammatory reactions. Controlled
hyperstimulation of the ovary especially puncture of the
ovaries in in-vitro fertilization (IVF) or intracytoplasmic
sperm injection (ICSI) cycles is an inflammatory process
leading to changes in CRP concentration, these changes may
affect success rate of IVF/ICSI and clinical pregnancy.
Patients whose CRP level decreased on transfer day, had
lower chance of pregnancy, whereas patients whose CRP
level elevated on embryo transfer day had high chance of
pregnancy.