الفهرس 
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Abstract
The present study comprised of 50 randomly selected paraffin blocks of primary colorectal adenocarcinomas cases including 18 cases with available their corresponding blocks of metastatic lymph nodes. They were obtained from the archives of histopathological laboratories of Minia University Hospital and Minia Oncology Center in the period between 2017 and 2019.
We studied the immunohistochemical expression of OCT-4 in CRC tissues and its association with different clinicopathological data. The expression of OCT-4 in primary tumor and corresponding lymph node metastasis was also evaluated.
In the present study, 16 cases (32%) showed high cytoplasmic OCT4 expression, while 34 cases (68%) showed negative/low expression. A statistically significant association was detected between OCT-4 expression and tumor grade (P= 0.005).
In addition, we found a statistically significant associations between cytoplasmic OCT-4 expression and lymph node metastasis (P= 0.048), advanced tumor stage assessed by both TNM staging (P= 0.003) and modified Dukes staging (P= < 0.001).
A significant association was also found between high OCT-4 expression and PDC grading (p= 0.002).
No significant associations were found between cytoplasmic OCT4 expression and either patients’ age, gender, tumor localization, TILs, tumor size, vascular invasion or perineural invasion (P= 0.258, P= 1.00, P= 0.09, p=0.135, P= 0.09, p=0.09 and 0.157 respectively).
On comparing OCT-4 expression in primary tumors and their matched LN metastases, no significant difference was detected (P= 0.157). Sixteen cases (88.9%) maintained the same expression score. Two cases (11.1%) changed OCT-4 expression score from high expression in primary tumor to negative/low expression in LN metastasis.