الفهرس 
SKIN AGINGOnly 14 pages are availabe for public view
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Abstract
The periorbital region is one of the areas showing the
earliest signs of aging and is especially prone to skin
wrinkles and discoloration. Therefore, patients often seek its
cosmetic rejuvenation.
Several treatment modalities have been investigated for
their potential role in the rejuvenation of photoaged skin.
Different types of Laser devices have been tried in the field of
photo-rejuvenation.
Fractional CO laser is one of the popular medical
procedures when it comes to treatment of wrinkles which can
be attributed to the safety and efficacy since it causes
microscopic routes that reaches the dermis and causes collagen
remodeling. Also using IPL for photorejuvenation has many
benefits including the ability to treat multiple aspects of
photoaging (pigmentation, telangiectasia, and fine wrinkling)
simultaneously, minimal patient discomfort and no down time
after treatments.
Fractional CO laser has greater efficacy in skin
tightening because of the pattern of thermal ablation, which
provides for deeper dermal penetration; also there is a bimodal
immediate collagen contraction and a second effect at -
months afterwards from persistent collagen remodeling.The present study aimed to compare the effectiveness of
fractional CO laser versus IPL in the treatment of periorbital
wrinkles using ANTERA D complexion analysis, as well as
treatment side effects.
The study was conducted on females suffering from
periorbital wrinkles from the outpatient clinic of Ain Shams
University Hospital. Patients received four treatment sessions
with three weeks interval on each side of the periorbital region.
Odd numbered patients had fractional CO laser on the right
side and IPL on the left side; while even numbered patients had
IPL on the right side and fractional CO laser on the left side.
All patients were subjected to history taking, digital
photography and complexion analysis using ANTERA D
camera. Assessment was done before each session and two
months after the last treatment session.
The mean age of patients was ± years with a
range of - years. The majority of cases ( ) had skin
type III. of patients had class I wrinkles according to
Fitzpatrick classification, whereas had class II wrinkles.
All patients showed improvement in the severity of
periorbital wrinkles in both sides after each session with
maximal percent at the follow up period. Both IPL and
fractional CO laser produced significant improvement in the
wrinkles indentation index.In the present study, there was a highly statistically
significant difference between the mean percentages of
improvement of the wrinkles indentation index by fractional
CO laser ( ± ) as compared to mean percentage of
improvement by IPL ( ± ). This improvement could be
explained by the fact that fractional CO laser has greater
efficacy in skin tightening because of the pattern of thermal
ablation, which provides for deeper dermal penetration.
There was a significant negative correlation between age
and the mean percentage of improvement of periorbital
wrinkles indentation index by using fractional CO laser.
However, there was no correlation between duration of
wrinkles and the mean percentage of improvement of
periorbital indentation index by using fractional CO laser.
On the other hand, no correlation between either age or
duration of wrinkles and the mean percentage of improvement
of periorbital wrinkles indentation index by using IPL was
found.
Treatment was well tolerated by all patients. The most
common side effects encountered were pain, transient
hyperpigmentation, and residual erythema which were non
significantly higher in fractional CO treated side. No
complications were reported at the last follow up visit. Thus, Fractional CO laser shows superior results in
improving periorbital wrinkles and is regarded as a safe and
effective treatment modality.