الفهرس 
Acknowledgement
ManagementOnly 14 pages are availabe for public view
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Abstract
Neonatal thrombocytpenia is widespread in preterm and term neonates admitted to neonatal intensive care units, with up to one-third of infants demonstrating platelet counts <150 _ 109/L. Thrombocytopenia .may arise from maternal, placental or fetal/neonatal origins featuring decreased platelet production ,increased consumption, or both mechanisms, Neonatal thrombocytopenia is extremely common and has a broad differential. It is important to factor in the timing of the thrombocytopenia, prenatal and maternal history, severity of the thrombocytopenia, and overall health of the infant. Although infection is the most common reason for early neonatal thrombocytopenia in sick infants, NAIT is the most common cause for well children.. Two subgroups can be distinguished: early thrombocytopenia, occurring within the first 72 hours of life, and late thrombocytopenia, occurring after the first 72 hours of life. Early thrombocytopenia is associated with intrauterine growth restriction, whereas late thrombocytopenia is caused mainly by sepsis and necrotizing enterocolitis (NEC) (Cremer et al., 2016b).
Current management including platelet transfusion. Furthermore, transfusions are the hallmark of the treatment of neonatal thrombocytopenia. Most of these transfusions are prophylactic, which means they are given in the absence of bleeding. However, the efficacy of these transfusions in preventing bleeding has never been proven. In addition, risks of platelet transfusion seem to be more pronounced in preterm neonates. Because of lack of data, platelet transfusion guidelines differ widely between countries (del Vecchio, 2014). The purpose of this study was to detect the incidence and risk factors of thrombocytopenia in newborn admitted to NICU of Assiut University Children Hospital.