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العنوان
Assessment of risk factors of epilepsy in Egyptian children with cerebral palsy /
المؤلف
Abu-Bakr, Magda Abu-Bakr.
هيئة الاعداد
باحث / ماجدة أبوبكر أبوبكر
مشرف / محمد مجدي علي أبوالخير
مشرف / خالد فتحي عبدالعزيز
مشرف / أشرف محمد عبدالرحمن
مناقش / أحمد رؤوف أحمد
مناقش / أمل محمد عثمان
الموضوع
Pediatrics. Cerebral palsy.
تاريخ النشر
2021.
عدد الصفحات
135 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
طب الأطفال ، الفترة المحيطة بالولادة وصحة الطفل
تاريخ الإجازة
1/6/2021
مكان الإجازة
جامعة المنصورة - كلية الطب - قسم طب الأطفال
الفهرس
Only 14 pages are availabe for public view

from 159

from 159

Abstract

Cerebral palsy (CP) is a non-progressive, mainly postural, motor impairment disorder of the developing brain which develops due to various causes during the intrauterine period, or shortly after birth (Gürkan et al., 2018). Epilepsy is known to have a higher association with CP. It is usually difficult to control and increases the severity of motor and cognitive disorders making the prognosis worse. (Rahmat et al., 2010). Epilepsy is highly correlated with CP: Epilepsy occurs in 35–62% of affected children. It is the leading cause of hospitalization in children with cerebral palsy (Falchek, S., 2020). Family history, structural abnormalities (primarily brain atrophy and gray matter involvement), neonatal seizure, low Apgar scores, and mental retardation are significant risk factors for the development of epilepsy in patients with CP. CP patients with spastic quadriplegia or acquired hemiplegia are more prone to seizures, whereas seizures are less common in mild symmetric spastic diplegia and CP that is mainly athetoid (Mesraoua,et.al, 2019). Risk factors for epilepsy in early childhood are neonatal seizures, complex febrile seizures (CFSs), infections, head trauma, vascular malformations, brain tumors, parasitic infections, stroke, inflammatory and autoimmune disorders, and limbic encephalitis (Potharaju, 2016). Aim of the work : This study aimed to identify the frequency of epilepsy between children with CP and various risk factors that may had affected the development of epilepsy. Materials and Methods: This study was a retrospective cross -sectional, analytic study held on pediatric neurology department and outpatient’s clinic of Mansoura University Hospital within one year on 176 children with CP (aged 2 to 18 years) and had been divided into two groups: group A: 96 CP child with epilepsy. group B: 80 CP child without epilepsy Results: In this study epilepsy was found in 96 children out of 176 CP patients i.e. (54.45 %).Some factors are believed to increase risk of epilepsy in CP children such as family history of epilepsy, Pregnancy order, large birth weight, vaginal delivery, Apgar score less than 4 at the first 5 minutes, neonatal seizures, and quadriplegic type of CP, and degree of severity of CP according to GMFCS. Level V had been determined as risk factors for the development of epilepsy in CP patients, and abnormality on MRI. Pregnancy order and Apgar score were significant predictors of epilepsy among studied groups. Conclusion: Epilepsy is known to have a higher association with CP. Predicting epilepsy development by determining the risk factors in patients with CP might be useful because knowing the risk factors could provide close follow-up of these patients. Further longitudinal studies needed to better understanding the causes of epilepsy in CP patients.