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العنوان
Candiduria in cancer patients :
المؤلف
Mohamed, Alaa Mohamed Morsi.
هيئة الاعداد
باحث / ألاء محمد مرسي محمد
مشرف / دعاء رأفت الديب
مشرف / مني عبدالمولي أحمد الوصيفي
مناقش / أحمد محمد الحنفي عليوة
مناقش / غادة محمد العقاد
الموضوع
Clinical Pathology. Cancer.
تاريخ النشر
2021.
عدد الصفحات
138 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
أمراض الدم
تاريخ الإجازة
1/6/2021
مكان الإجازة
جامعة المنصورة - كلية الطب - قسم الباثولوجيا الإكلينيكية
الفهرس
Only 14 pages are availabe for public view

from 138

from 138

Abstract

Candiduria is a type of infection in immunocompromised patients especially cancer patients due to chemotherapy, invasive device use and intensive antibiotic administration.It is caused by C. albicans or non –albicans. Early diagnosis of candiduria is very important for proper treatment and decrease economic burden. It is done by urine analysis, culture, species identification by colony morphology, Germ tube test, biochemical characterization, serological methods, molecular methods and antifungal susceptibility testing either manual by disc diffusion method or automated by MIC method as done in automated Vitek2 system. This study was conducted on 51 urine samples that obtained from a total of 2260 patients suspected to have UTI (68.6% were catheterized) received in OCMU laboratory during the period from January to December 2019. All samples were examined macroscopically and microscopically by Gram stain then cultured on CLED and SDA at 37°C for 24-48h. The 51 isolates proved to be candida species were subcultured on CandiSelect4 chromogenic media and undergo antifungal susceptibility pattern. Only 40/51 isolates undergo identification and antifungal susceptibility by automated vitek2 system. The current study shows percentage of candiduria as 2.3% in the studied cancer patients with predominance in females and cathetrerized patients. C. albicans is the most frequent identified species by CandiSelect4 chromogenic media and by automated Vitek2 system. Azole resistance in disc diffusion method is 83.5% while that for MIC method by Vitek2 system is 16.2%. AmphotricinB sensitivity in disc diffusion methos is 49% while that for MIC method is 100%. So MIC is better than disc diffusion method for antifungal susceptibility.