الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 91 |  |  |
| | | from | 91 | | |
Abstract
MSG is a widely used flavoring food additive that’s found in many foods as Indomie, Asian cooking, packaged, and fast food. It exerted multiple side effects including adrenal toxic effects.
The study aimed to demonstrate the injurious effects of MSG on the adrenals of female albino rats and its potentiality to cross the placental barrier carrying its injurious effects to their pups.
Twenty-five female albino rats weighing about 200g were mated and bred, then separated into two groups.
group I (control): 10 rats, recieved a daily dose of distilled water equal to the dose given to the other group.
group II (MSG): 15 rats, each received 10 g/kg MSG, orally, starting on day 7 of gestation and till day 20.
The rats were weighed, blood samples collected, and sacrificed 1 day after delivery, their adrenals were dissected, weighed, and examined by light and electron microscope.
The study revealed that MSG caused a significant increase in the final body weight and decrease in the adrenal weight of both MSG-treated mothers and pups in comparison with the control group. As well as a decrease in the corticosterone level in the MSG-treated mothers.
Histologically, MSG-treated mothers and their pups showed many degenerative changes, with apparent thinning of the capsule that was further confirmed by Masson trichrome stain, a disorganized structure of the ZG and ZF, and areas of cellular shedding and hemorrhagic sites were noticed. Shrunken nuclei and degenerated mitochondria with disrupted cristae and penetration of the lipid droplets to form “myelin-like” structures were noticed by ultrastructural examination.