الفهرس 
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Abstract
Fenofibrate is used to treat severe hypertriglyceridemia and mixed dyslipidemia in patients who have not responded to non-pharmacological treatments. Coenzyme Q10 is a lipid-soluble molecule which has a number of vital functions within the cell. The aim of this work was to detect histological and immuno histochemical changes in the soleus muscle of adult male albino rats after administration of fenofibrate and to elucidate the potential protective effects of coenzyme Q10. This study was conducted on sixty adult male albino rats, aged between three and four months, and weighing 180-200 gm. The rats were divided into six groups, ten rats in each group. The control group was fed on the basal diet only. The vehicle control group received 2 ml 0.5% carboxymethyl cellulose by gastric tube for 4 weeks. CoQ10 treated group received 100 mg/kg/day of CoQ10 powder dissolved in 2 ml 0.5% carboxymethyl cellulose by gastric tube for 4 weeks. Fenofibrate treated group received fenofibrate (repeated daily) 60 mg/kg suspended in 2 mL 0.5% carboxymethyl cellulose daily by gastric tube for 4 weeks. The recovery group received fenofibrate as fenofibrate treated group for 4 weeks, and treatment was stopped for 4 weeks. The group treated with fenofibrate and coenzyme Q10 received fenofibrate as the fourth group and coenzyme Q10 as the third group for 4 weeks. At the end of the experiment, animals were anesthetized by intraperitoneal injection of sodium pentobarbital and then blood samples were collected from the tail vein of all animals for determination of creatine kinase level. Parts of the soleus muscle of the right hind limb of all animals were obtained rapidly, put in the cryostat for succinic dehydrogenase demonstration to differentiate between type I and type II fibers. The soleus muscle of the left hind limb of all animals were obtained for histological study. Paraffin sections were prepared and stained with (H&E), Mallory’s trichrome stain and immuno histochemical stain with anti-caspase 3. For TEM examination, semithin sections and ultrathin sections were prepared. Statistical analysis of biochemical parameter and the number of degenerated fibers were counted in hematoxylin and eosin-stained sectors in all groups was also performed. We have demonstrated that the use of CoQ10 as adjuvant therapy protects against the side effects of fenofibrate in skeletal muscle. The toxic effects of fenofibrate on skeletal muscle were partially reduced when fenofibrate was stopped.