الفهرس 
Vitamin DOnly 14 pages are availabe for public view
 |  | from | 176 |  |  |
| | | from | 176 | | |
Abstract
Besides its well-known effects on calcium/phosphate homeostasis, vitamin D influences muscle function, cardiovascular homeostasis, nervous function, and the immune response. Most importantly, low vitamin D status has been found to be an independent predictor of all-cause mortality.
The aim of this study is to investigate the role of empirical vitamin D (200,000 IU) single dose supplementation in hospitalized patients and its impact on the length of stay and outcome of hospitalization.
Our study was conducted on 80 patients, selected from internal medicine wards of Ain shams university hospital admitted between January and June 2019 Patients of both genders, of age more than 21 years old, admitted with acute deterioration of their chronic illness, 40 patients suffering from chronic liver diseases (most of patients were child C on Child-Pugh score) and 40 patient with heart failure (most of patients with ejection fraction <35% diagnosed by echocardiogram) were recruited. 20 patients of each group (Intervention group) received single dose vitamin D within 3 days of admission, and the other 20 patients of each group (No Intervention group) did not receive vitamin D. We exclude patients admitted with diagnoses other than the two selected disease groups. Also, patients admitted to surgery or gynecological departments were excluded.
All participants were subjected to full medical history taking, General clinical examination and Laboratory investigations including (25 hydroxy vitamin D level, PTH, corrected serum calcium, phosphorous, CBC, liver profile, renal profile tests and). After measurement of vitamin D level, the patients were classified according to their vitamin D status into: severe deficient group (vitamin D level < 10 ng/ml), deficient group (vitamin D level from 10 to 20 ng/ml), insufficient group (vitamin D level 20 to 30 ng/ml). sufficient group > 30 ng/ml.
Our results revealed no significant difference between patients who received vitamin D supplementation and who did not receive vitamin D supplementation as regards outcome and survival with P value 1.000 in patients with CLD and 0.823 in patients with CHF.
But on the other hand, we found baseline vitamin D level was an independent predictor of mortality (P value .018).
In conclusion we found that a beneficial effect of empirical vitamin D supplementation can’t be achieved with single dose vitamin D (200,000 IU) on CHF and CLD hospitalized patients’ mortality. We recommend that vitamin D supplementation should be considered in CLD and CHF outpatients, with exception of hypercalcemic and hyperphosphatemic patients, as baseline vitamin D status affects the disease course and mortality prior to disease deterioration and hospitalization.