الفهرس | Only 14 pages are availabe for public view |
Abstract Hepatocellular carcinoma (HCC) is one of the most common types of cancer in the world, accounting for 85- 90% of the total primary liver cancer burden worldwide. It is also the second most frequent cause of cancer-related mortality. In Egypt, HCC is the second and fifth most common malignancy in men and women; respectively. The rising incidence of HCC may be due to high prevalence of HCV and its complications. Risk factors of HCC can be broadly classified into genetic, clinical and environmental, in genetic risk factor, the most common type of genomic sequence variation is single nucleotide polymorphisms (SNPs) and is thought to be associated with population diversity, susceptibility to disease, and individual response to drug treatment. Clinical risk factors include: cirrhosis, chronic hepatitis C virus (HCV) infection, chronic hepatitis B virus (HBV) infection, Co-infection of HBV and HCV virus, schistosomiasis, alcoholism, aflatoxin B1 (AFB1) and diabetes mellitus (DM). Environmental risk factors include pesticides and cigarette smoking. Matrix metalloproteinases-11 (MMP-11) is one of MMPs family, and it is known as stromelysin-3, it plays an important role in intense tissue remodeling during embryogenesis, as well as tissue involution and it has been observed during wound healing in normal physiologic conditions. However MMP-11 is unlike most MMP family members which does not cleave major components of the ECM, the laminin receptor, insulin-like growth factor binding protein 1, collagen VI, and α1-proteinase inhibitor are major substrates of MMP-11. |