الفهرس 
Aging
DNA damage response (DDR)Only 14 pages are availabe for public view
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Abstract
Aging is a process of progressive loss of physiological integrity. There
are many theories that explain aging process. DNA damage,cell senescence
and oxidative stress are considered the most accepted mechanisms of aging.
DNA damage is a major factor associated with the development and
progression of age-related degenerative disorders.DNA damage may affect
the expression of a variety of genes involved in the regulation of cell
proliferation or inhibit expression of other genes associated with DNA
repair.Organisms are often exposed to environmental and internal challenges
that cause DNA damage, efficient and accurate DNA repair systems ar
crucial for maintaining genome integrity and organism subsistence.For
instance, non-homologous end joining and homologous recombination are
the two major mechanisms responsible for efficient repair of DNA doublestran
breaks(DSBs)which is considered the most harmful type of DNA
damage.