الفهرس 
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Abstract
This study was carried out to investigate the feasibility of using the MRI BIRADS Lexicon descriptors to predict the molecular subtypes of breast lesions in MRI. Starting with the clinical presentations of breast lesions of different molecular subtypes. Nipple retraction and skin retraction were detected in breasts with ER -ve lesions (in particular, Her2neu. As for mastalgia, 60% of the patients with non-luminal lesions were clinically presented with it. Patients underwent breast MRI. Lesions were distinguished into mass lesions and non-mass lesions. Luminal subtype was more frequently represented as mass lesions. While NME was more frequently reported with hormonal negatives statuses and non-luminal lesions. Focusing on the non-luminal lesions, TN breast cancers were also more frequently represented as mass lesions while Her2neu lesions showed NME more frequently. The pre-contrast images (T2WI) of these lesions were beneficial to detect high T2SI of the tumor and peritumoral edema. Peritumoral edema was more frequently associated with ER-ve lesions. Regarding post contrast sequences were used to study the morphological criteria of the lesions, either mass or non-mass lesions, moreover, the dynamic time-intensity curve aided in sorting the different molecular subtypes. The morphological criteria of the mass lesion including margin, shape and internal enhancement patterns were studied. Margin of Luminal A subtype lesions were more frequently irregular while margin of Luminal B lesions was more frequently spiculated. TN negative lesions were smooth in outline while those of Her2neu lesions were more frequently spiculated. Regarding shape of the lesion, there was an association between shape of the mass and non-luminal subtypes where triple negative subtype mass lesions were more frequently round. Irregular shape was detected more in luminal lesions. As for internal enhancement patterns, triple negative mass lesions were more frequently represented by rim enhancement than other enhancement patterns, while the heterogenous pattern was more frequent in Her2neu mass lesions. On the other hand, dark internal septation pattern more frequently represented the luminal subtype.