الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Periodontitis is a major oral health problem that threatens the survival of teeth and affects the quality of life. It is frequently associated with the formation of intrabony defects, which complicates the condition and deteriorates the prognosis of associated teeth.
Advanced platelet-rich fibrin (A-PRF) is a recent purely autologous platelet concentrate prepared using the “low speed concept”, developed by Choukroun et al. This preparation protocol results in amplifying the amounts of platelets, growth factors and leukocytes within a dense fibrin matrix. The formed structure allows A-PRF to act as a scaffold containing all components and cells crucial for wound healing and regeneration. Moreover, A-PRF was found to contain the highest content of white blood cells, the key regulators of inflammation.
Thus, our study was conducted to investigate the ability of A-PRF to achieve periodontal regeneration, when added to biphasic alloplast in intrabony defects, measured both clinically and radiographically.
The current study included twenty two intrabony defects in twenty two chronic periodontitis patients, which were randomly allocated to one of the two equal study groups. Test group treated with A-PRF mixed with biphasic alloplast, was compared to the active control group treated with the biphasic alloplast mixed only with saline.
Evaluated parameters were plaque index, modified gingival index, probing depth, clinical attachment loss, alveolar crest height, percentage of bone fill and estimated bone density.
Summary
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The tested biomaterial showed more improvement in all clinical and radiographic parameters than the biphasic alloplast. As expressed by the higher probing depth reduction, clinical attachment level gain, bone fill percentage and estimated bone density in test group than the control group. As well as, the alveolar crest bone formation seen only in A-PRF group.
Our results indicate that A-PRF is a valuable addition to periodontal regeneration of intraosseous defects in chronic periodontitis cases.