الفهرس 
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Abstract
Long term stability is the major goal of orthodontic treatment.
Hence, a series of safe pharmacological agents have been experimented to
increase osteoblastic activity around orthodontically moved teeth to help in
retention and stability of their correction.
Aim of the study: To evaluate the effect of systemic administration of Omega-3
on post-orthodontic relapse, and histological bone changes concurrent with
Omega-3 administration in rabbits.
Materials and Methods: Thirty two male rabbits, divided equally and randomly
into two groups. Both received NiTi coil springs installed on mandibular first
molar and ligated to anterior incisor; experimental group with omega-3 and
control group with saline. Omega-3 and Saline were given from day one of
orthodontic tooth movement till end of relapse period by oral gavage. After 21
days of OTM, all appliances were removed to allow relapse; then impressions
and measurements were taken immediately, on day 28 and on day 42 before
animal euthanasia for histological analysis.
Results: A significant difference in relapse percentage was observed on the 3rd
week of relapse, with mean (66 ±6 %) and (75.22 ± 13.61%) for experimental
and control groups respectively. Histologically, experimental group had showed
few figures of bone resorption on the distal aspect of the first molar with
prevailing appearance of osteoblastic activity intervening between occasional
resorptive figures. A Significant increase in serum alkaline phosphatase
confirmed the clinical and histological results in experimental group.