الفهرس | Only 14 pages are availabe for public view |
Abstract Erectile dysfunction is defined by the Fourth International Consultation on Sexual Medicine as the consistent or recurrent inability to attain and/or maintain penile erection sufficient for sexual satisfaction. Normal sexual function has been described as a biopsychosocial Process that involves the coordination of psychological, endocrine, vascular, and neurological systems. Erectile dysfunction is classified as psychogenic, organic (i.e., neurogenic, hormonal, arterial, cavernosal, or drug-induced), or mixed psychogenic and organic. Erectile dysfunction is usually of a mixed psychogenic and organic nature. Risk factors for ED include age, diabetes, hypertension, obesity, lack of exercise, dyslipidemia, smoking, depression, lower urinary tract symptoms, and pelvic surgery. Melatonin is the main hormone secreted by the pineal gland. It is mainly synthesized by the pinealocytes from the amino acid tryptophan Melatonin received much attention from researchers in the last decades and apart from being an inducer of sleep, many other vital functions were discovered. One of these is the regulation of the hypothalamo-pituitary-gonadal axis. It was proved that; its elevation causes inhibition of the whole axis. Its exact role in ED is unclear and very little researches exist. So, we aimed by this work to spotlight on its relation to ED through measuring its level and to find out its correlation with clinical data. This case control study included 60 patients with erectile dysfunction and 30 age-matched healthy controls. After taking history and doing a clinical examination, we measured melatonin, CBC, ALT, AST, HbA1c, TT, FT, and Prolactin. |