الفهرس 
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Abstract
This study was designed to determine the frequency HSV1/2 antibodies and their value in the pathogenesis of SLE and lupus nephritis. This study was approved by ethical committee of faculty of medicine, Assuit University, approval number 17101182 at 6/11/2016.Each subject or his parent / guardian gave an informed consent before being included in the study. Patients were recruited from the Rheumatology Clinic, Department of Internal Medicine, Assiut University hospital, Assiut, Egypt from January 2018 to May 2019. Their age ranged from 18 -54 years (Mean ± SD = 30.73 ± 8.5 years). Ninety SLE Patients were subjected to complete history taking and clinical examination to assess clinical signs and symptoms of systemic lupus disease. Their age ranged from 18 -54 years. Also, 83 apparently healthy female were included in the study as control group. Their age ranged from 15-45 years (Mean ± SE= 32.06 ± 7.3 years). The following laboratory investigations were done: 1-Complete blood count (CBC) and reticulocytic count for patients and control subjects. 2-Direct Coombs test for SLE patients with anemia and/or reticulocytosis (28 patients) 3- Erythrocyte sedimentation rate (ESR) for SLE patients. 4- Serum urea, creatinine and albumin for patients and control subjects. 5-C reactive protein (CRP) for patients. 6- Antinuclear antibody (ANA) for SLE patients and control subjects. 7- Anti-dsDNA antibody for SLE patients. 8-C3 and C4 for SLE patients. 9- Urine analysis, 24 urinary protein level and creatinine clearance were done for SLE patients. 10-Anti-Herpes Simplex Virus (1/2) IgM and IgG antibodies for SLE patients and control subjects were done. Hemoglobin level showed a statistically significant decrease in SLE patients group (mean ± SD=10.77 ± 1.5gm/dl) when compared to the control group (mean ± SD=11.8 ± 1.2gm/dl). Also there was a statistically significant.