الفهرس 
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Abstract
Toxoplasma gondii is a common zoonotic intracellular protozoan infection of approximately one-third of the world’s human population. Latent toxoplasmosis has been considered asymptomatic and only associated with pathogenesis in the immunocompromised host for long years. However, recent studies have shown a strong association between toxoplasmosis and psychotic disorders, especially schizophrenia. But the exact mechanism is not yet well understood. Previous studies show that psychiatric disorders are mostly mediated through both an immune reaction of the brain to T. gondii infection, which affect glutamatergic systems and the biochemical activity of the parasite itself, which affect dopaminergic systems. Multiple in vitro studies showed that many antipsychotic medications have anti toxoplasma activity. Meanwhile, there is very limited data regarding the inhibitory effect of them on Toxoplasma in in vivo. Hyperprolactinemia is a common side effect of antipsychotics. Prolactin has been demonstrated to have antiparasitic activity against the T. gondii infection by different studies. Yet, in antipsychotics the effect and mechanism on Toxoplasma are unknown. This study was designed to detect the possibility of controlling Toxoplasma infection in experimental animal models using prolactin and antipsychotic drugs, also, to investigate the mechanism of its action. In the present study, oral chlorpromazine, clozapine, and metoclopramide drugs were used for three weeks in the treatment of female albino Wistar rats infected two months ago with T. gondii RH strain. Rats were classified into 8 groups: 3 infected treated groups, 3 drug control group, negative, and positive control groups each one of them contained 6 rats. All rat’s sera screened with ELISA test to detect the level of dopamine, interferon gamma, and prolactin and compared to its matched control group. The infection was ascertained using the modified agglutination test and histopathology examination of rats’ brains. Results indicate that all of CHZ, CLZ, and MTP were effective against Rh strain of T. gondii in tested infected rats. Moreover, the typical antipsychotic CHZ has the strongest and way better impact between them. DA level and INF-γ level significantly decrease in CHZ infected treated group. Furthermore, PRL level significantly increased in it. CLZ has a moderate anti-Toxoplasma activity as biochemical finding showed significant decrease of DA level and increase of PRL level in CLZ infected treated group. Also, MTB has a moderate inhibitory effect. Biochemical finding showed that it significantly increases prolactin level, and significantly decrease INF-γ level. So, based on our results, it could be assumed that higher levels of the PRL in patients’ sera may restrict, to some extent, the growth of T. gondii tachyzoites.