الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
The LIFE (Liver Injury Failure Evaluation) score is a disease-specific score, i.e., a liver-injury score used in critically ill patients proposed to predict outcome in critically ill patients who admitted in ICU suffering from chronic liver disease, it is practical and easy score for discriminating between those with acute liver failure and those without. They retained three factors, bilirubin, INR and arterial lactate to determine the association between it and in-hospital mortality.The liver, which is responsible for 60% of systemic lactate metabolism, is a vulnerable organ during sepsis-related acute circulatory dysfunction. The contribution of the liver to persistent hyperlactatemia might be much higher than previously thought. Hepatic injury in ICU can emerge either as a rapid primary episode caused by an acute reduction in perfusion or as a late-onset form of hepatic injury, the liver dysfunction is accompanied by high levels of hepatic enzymes reflecting the hepatotoxic action of inflammatory mediators which increased mortality and length of stay in ICU. Oxidative stress is evident from high levels of biomarkers of oxidative stress, such as reactive oxygen species (ROS), free radicals, MDA, and inflammatory cytokines. Critically ill patients have decreased plasma and intracellular levels of chemical antioxidants. Aim of the work: - Early detection of acute liver dysfunction using new score (lIFE score) and its impact on mortality in ICU critically ill patients and hospital stay length and to compare the Life score in hepatic ICU patients with that of the other critically ill ICU patients. To assess the impacts of change in serum lactate, GSH, TNF and MDA on the outcome in ICU critically ill patients and hospital stay length.Our study was case control study of 154 patient, 77 patients of them had chronic liver diseases as the cases and 77 of them didn’t have chronic liver diseases as controls, all were admitted at Assuit university hospital ICU. In trial to illustrate the value of LIFE score in early detection of acute liver failure or injury on top of chronic liver diseases and its prediction of short- and long-term ICU mortality and hospital stay period.