الفهرس 
FTIR Spectroscopy
Non-invasive Optical Spectroscopy for Skin AnalysisOnly 14 pages are availabe for public view
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Abstract
This thesis aims to study the development of miniaturized systems for meas-urement of Blood Alcohol Concentration (BAC) and Blood Glucose Concentration (BGC) non-invasively through the human skin, using a Fourier Transform Infrared (FTIR) spectrometer based on Micro-Electro-Mechanical Systems (MEMS) technolo-gy. The spectrometer is micro-fabricated on a single silicon chip with Michelson in-terferometer as its core engine. This solution promises low cost and high scalability which is suitable for wearable applications. However, the miniature size of the system limits the optical throughput. Different aspects related to the MEMS spectrometer configuration and the safety of its operation on the skin are investigated. This is fol-lowed by the design and implementation of the optical probe used for the non-invasive measurements. This includes the modeling of light transport to acquire dif-fuse reflectance spectroscopy (DRS) from the human skin for the optimization of the useful signals.
Furthermore, simulations are used to study the requirements of the application accompanied by chemometric analysis. Then, experimental studies are performed on humans to measure blood glucose concentration. Finally, to push the performance of the MEMS FTIR spectrometer, parallel interferometers operating on the same MEMS chip are used. This concept is implemented and characterized for enhancing the spectral range and the SNR.