الفهرس 
Antimicrobial agentsOnly 14 pages are availabe for public view
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Abstract
Overcome the microbial resistance to drugs is a challenging objective for pharmaceutical scientists. Alternative strategies are being employed to combat multidrug-resistant pathogens by repurposing already approved drugs that have antibacterial activity and co-administered them with antimicrobial agents. Combination therapy can be a useful technique since we can take advantage of the synergistic action of the combination against the different pathogens. The combination drugs can broaden the antibacterial spectrum and decrease the emergence chances of new antimicrobial resistance. Statins are members of a pharmaceutical class that is widely used to reduce high serum cholesterol levels. As well, statins have so-called ―pleiotropic effects‖. Statins have gained attenuation as an antimicrobial agent as an increasing number of studies are detailing in vitro and in vivo effect of statins on bacterial infection. Accordingly, the objective of this work was to evaluate the activities of statins individually and in combination with antibiotics to enhance antimicrobial activity and reduce resistance to drugs. To achieve this objective rosuvastatin and atorvastatin were selected to test the effect of these compounds as antimicrobial agents, both in vitro and in vivo. S. aureus and Ps. aeruginosa were utilized as the test bacteria. Our MIC values demonstrate the ability of our tested statins to induce antibacterial activity against S. aureus and Ps. aeruginosa reference strains, as well as MDR, isolates at variable degrees, with rosuvastatin being the most effective among the studied statins and was active against both gram-positive and gram-negative MDR bacterial isolates. The results indicated that both rosuvastatin and atorvastatin possess bacteriostatic activity against both tested S. aureus and Ps. aeruginosa isolates.