الفهرس 
List of contentsOnly 14 pages are availabe for public view
 |  | from | 132 |  |  |
| | | from | 132 | | |
Abstract
Background : Multiple factors play a role in the development of dental decay, including microorganisms, diet, oral hygiene, medical conditions, and lack of important nutrients, such as vitamin D. Aim of the study: This study aims to evaluate the association between the VDR gene polymorphism and deciduous teeth decay in children and correlate it to Streptococcus mutans count. Methodology: Case-control study design was used. One hundred and fifty children were involved and divided into two groups; GpI: 75 patients with deciduous tooth decay; and GpII: 75 children free from dental caries as a control group. Two types of samples were taken from each patient; saliva sample for Streptococcus mutans detection and buccal cells sample for vitamin D receptor gene polymorphism (VDR) assay. Results: S. mutans count was higher in cases than control group and showed statistically significant difference (p=0.0002). Frequency of GG genotype was higher in control (86.7%) than cases group (64.0%) while GT genotype was higher in cases (36.0%) than control group (13.3%). Risk ratio of GT/GG in cases vs control was significant (p=0.001). Conclusions: GT genotype support the growth of some bacteria in the oral cavity. S. mutans count was higher in GT genotype, so people with GT genotype are more susceptible to develop dental caries by 3.65 fold and suffer from more DMFT. Susceptible people should increase care of mouth hygiene.