الفهرس | Only 14 pages are availabe for public view |
Abstract Ovarian cancer is a commonly diagnosed and deadly gynecologic malignancy worldwide. Ovarian carcinomas account for the majority of cancer-related deaths in women among the cancers of the female reproductive tract Borderline ovarian tumors (BOT) are uncommon but not rare epithelial ovarian neoplasms, intermediate between benign and malignant categories. IMP3 has gained considerable interest as a cancer-associated protein.IMP3 overexpression has been reported in a variety of human types of cancer, including lung cancer, germ cell cancer, colon cancer, pancreatic cancer, gastric cancer ,liver cancer, and kidney cancer, and has been linked to advanced disease stage and adverse clinical outcome in some of these cancers. To contribute to the controversial discussion about the expression of IMP3 on surface epithelial tumors of the ovary, we examined the expression of IMP3 by means of immunohistochemistry. In this study, 43 collected cases of ovarian surface epithelial tumors (11 High grade serous carcinoma, 6 low grade serous carcinoma,10 Borderline serous tumor, 8 Mucinous carcinoma, 8 Borderline mucinous tumor) were included and their clinico-pathological data including : ( age of the patient, histological type of the tumor, FIGO staging of the tumor, unilateral or bilateral involvement of the ovaries, cystic component, papillary component & receiving neo-adjuvant therapy ) were assessed. |