الفهرس | Only 14 pages are availabe for public view |
Abstract Prior to the identification of H. pylori, studies demonstrated a greater incidence of COPD and tuberculosis in patients with peptic ulcers compared with the general population. Research has suggested a potential mechanism of the relationship between H. pylori and pulmonary diseases. Since H. pylori is a Gramnegative bacterium, lipopolysaccharide is one of the main compositions of its wall, which stimulates production of proinflammatory cytokines, such as interferon alpha, and interleukins 1, 2, and 8, leading to chronic inflammation, stimulation of the immune system, and cancer. We conducted this case control study to assess relationship between H. pylori infection and different pulmonary disease on 60 subjects at Chest Department Menoufia University hospital divided to six groups, group I included 10 COPD patient, group II included 10 asthmatic patient, group III included 10 patient with interstitial lung disease, group IV included 10 patient with bronchiectasis, group V 10 patient with malignancy and group IV included 10 healthy control subjects. All patients subjected to full history, general and local examination of the chest, radiological investigation in the form of chest x ray(PA – Lateral ) and CT if needed, immunoassay to measure immunoglobulin G (Ig-G) antibody titer in serum sample and spirometry with reversibility tests including (FEV1, FVC, FEV1 /FVC, FEV 25-75% & MVV) . Pathological examination were done to lung biopsy taken from malignant group |