الفهرس 
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Abstract
The main goal of the study was to estimate the genotoxicity of silver nanocomposites of different medicinal plant latex. Green synthesis approach was used to prepare silver nanoparticles from latex of suggested taxa including Cynanchum acutum L., Ficus carica L., Ficus elastica Roxb. ex Hornem. and Ficus sycomorus L. The study included phytochemical analysis for the studied taxa latex in order to demonstrate the bioactive compounds in latex. To estimate the safety of using of studied taxa latex in medical purposes, the concentration of heavy metal contamination was determined in addition to the cytotoxic and genotoxic studies for the crude latex and the biosynthesized silver nanoparticles. Vicia faba assay has been used for the cytotoxic and genotoxic studies. By increasing the concentration of Cynachum auctum and Ficus carica silver nanoparticles in the treatments, the mitotic index was decreased. Opposite to F. sycomorous, MI increased by increasing in AgNPs concentration. Percentage of chromosomal aberration induced by C. acutum 3% crude latex was lower than its silver nanoparticles. In contrast, F. sycomorous 3% latex induced the highest percentage of CA among all of its treatments. CA% of F. carica and F. elastica 3% latex treatments were higher than that of 25 ppm and 50 ppm their silver nanoparticles treatments, and subsequently their crude latex could be considered to be more toxic than low concentrations of silver nanoparticles. Genomic template stability is a qualitative measure reflecting the changes in SDS-PAGE and ISSR profiles generated by silver nanoparticles in relation to the profiles obtained from the control sample. GTS % reduced by increasing the concentration of silver nanoparticles of C. acutum, F. carica and F. elastica.