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Abstract Acute occluding of major epicardial coronary artery usually leading to acute STEMI. Successful recanalization and patency of the occluded vessels by (PCI) or fibrinolytic diminishes the infarction size, save the function of ventricle and decrease morbidity and mortality Several consequences such as no-flow and slow-flow, associated with more major adverse cardiac events (MACE), complications and high mortality, have been observed in patients with acute MI (AMI) and undergoing primary PCI Platelet aggregation into the distal microvasculature or thrombus embolization after immediately successful intervention impair microvascular flow. Glycoprotein IIb/IIIa inhibitors (GPI) administration and many catheter based strategies have been submitted to overcome this phenomenon. |