الفهرس 
Incidence and prevalenceOnly 14 pages are availabe for public view
 |  | from | 174 |  |  |
| | | from | 174 | | |
Abstract
Summary and Conclusion Psoriasis is one of the common skin diseases world-wide, affecting approximately 2–4% of the population worldwide. It is a chronic, complex, systemic, immune-mediated inflammatory disease with an extensive emotional and psychosocial effect on patients. Although exact etiology of Ps is not fully understood, genetic and environmental factors along with immune system may contribute in the development of Ps.Psoriasis presents clinically as sharply demarcated erythematous plaques with adherent silvery white scales. Plaque Ps is the most common clinical subtype. It can start at any age and affects both sexes equally. Abnormal epidermal differentiation, hyperproliferation, loss of granular cell layer, parakeratosis, inflammation and angiogenesis are common histopathological changes in Ps.
Cysteine-rich protein 61 (CYR61/CCN1) is a multifunctional nonstructural protein found in the extracellular matrix. It is a member of a large family of matricellular proteins. Based on structural homology, CCN proteins comprise a family of six members, CCN1-6. CCN1 regulates cell proliferation, migration, adhesion, angiogenesis, tumorigenesis and inflammation. It could be an important regulator in skin biology since it impacts both epidermal keratinocytes and dermal fibroblasts. It has been shown to be highly expressed in many autoimmune and inflammatory diseases, such as Ps, Sjogren’s syndrome (SS) and systemic lupus erythematosus (SLE). CCN1 promotes excessive activation of keratinocytes, which is important in the pathogenesis of Ps.