الفهرس 
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Abstract
Intraventricular hemorrhage is a major cause of morbidity and mortality in
preterm neonates. Elucidation of the mechanisms underlying Intraventricular hemorrhage
and/or development of disease biomarkers is essential.
Due to advances of prenatal, perinatal, and neonatal medicine survival rates of
preterm infants are increasing within the last decades. Nevertheless, this patient group is
at high risk for developing severe complications. Intraventricular hemorrhage remains
one of the main predictors of neurodevelopmental outcome in preterm infants. Although
Intraventricular hemorrhage incidence has decreased during the last decades, it still
ranges between 15 % and 45 % in very low-birth-weight infants with a significant higher
occurrence in extremely low-birth-weight infants.
In very preterm infants receiving intensive care, major intraventricular
hemorrhage has been reported to be the most common cause of death and long-term
neurodevelopmental disabilities in survivors. The high incidence of intraventricular
hemorrhage and its consequences among very preterm neonates accentuate the need for
further elucidation of the mechanisms underlying intraventricular hemorrhage as well as
the development of biomarkers for the early detection of high-risk infants and
prognostication of the outcome. Although several potential biomarkers have been studied
in premature infants with intraventricular hemorrhage, their usefulness has not gained
wide clinical acceptance.
Metabolomics involve the development and application of unbiased/global
analysis of various biological samples offering great potential for a holistic exploration
of the disease pathophysiology and/or development of diagnostic-prognostic biomarkers.
Mass spectrometry and nuclear magnetic resonance spectroscopy are the prevailing
analytical techniques used in this field.
The aim of the present study was to evaluate the relationship between urinary
levels of organic acids and early occurrence of intraventricular hemorrhage in preterm
neonates.
This was a prospective case control study was conducted on 40 preterm infants;
20 cases with interaventricular hemorrhage admitted to neonatal intensive care unit of
Menoufia University Hospital full-filling inclusion and exclusion criteria after writing
consent from parents and 20 preterm newborns with no intraventricular hemorrhage as a
control.
The main results of the study revealed that:
As regard demographic criteria, 80 % of IVH group and Control group was male,
there was significant difference between the 2 groups regarding the weight of
neonates as it was lower in group 1 (cases) than in group 2 (control) (1571.50±361.68
and 2195.0±270.43 g,p<0.001) .There is no significant difference between the 2
groups aregarding to the GA as it was lower in group 1 (cases) than in group 2
(control) (32.05±2.16 and 32.75±2.07,p=0.303), the maternal age (22.55±3.17 and
23.10±3.35,p=0.597) and mode of delivery as it shows that the normal delivery was
higher in group 1 (cases) than in group2 (control).