الفهرس 
GENERAL INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Apigenin is a natural flavonoid has a varied range of activity against number of diseases. However, its erratic and low dissolution affects its onset of action. Enhancing the dissolution rate to apigenin is needed to obtain rapid effect. It has been proved that arginine and meglumine have high potential for enhancing the dissolution rate of many drugs. Accordingly, the objective of this work was to investigate the effect of co-processing of apigenin with arginine and meglumine on its crystalline structure and dissolution rate. In addition to the dissolution enhancement development of orodispersible tablets which is suitable for prophylaxis and treatment for many types of cancer will make a great benefit. Apigenin was mixed with increasing molar ratios of arginine and meglumine before ethanol-aided kneading. The resulting products were examined using Fourier transform infrared spectroscopy, differential scanning calorimetry, and X-ray diffraction and also the dissolution behavior monitored. Instrumental analysis proved new crystalline species of apigenin formed with a great possibility of salt formation depending on pKa values for apigenin, arginine and meglumine. These crystalline structure modifications showed a significant increase in the dissolution rate of apigenin. The study introduced arginine and meglumine as potential excipients for enhanced dissolution of apigenin after wet co-grinding.
Objectives and Scope of the work:
The objective of this work is to optimize the dissolution rate of apigenin. The goal will be extended to develop rapidly disintegrating tablets with subsequent fast dissolution. This will be achieved as follow:
1. Development and validation of suitable method for quantification of Apigenin.
2. Determination of the dissolution rate of the unprocessed drug.
3. Investigation of crystalline structrure modification as a tool for enhancing the dissolution rate of apigenin.
4. Preparation and evaluation of rapidly disintegrating tablets.
Organization of the thesis
The thesis consists of the following main three chapters.
Chapter 1: contains a general introduction about apigenin activity and its pharmacokinetics and pharmacodynamics with a brief illustration on the dissolution process. In addition to authors studies about the dissolution enhancement techniques especially related to the drug and co formers used.
Chapter 2: shows detailed description about formulation process and materials used in this technique with adding the details about instruments used and materials and methods of calculations involved.
Chapter 3: provides the results and discussions, which divided into five parts:
1. Spectroscopic analysis of apigenin and method validation.
2. Characterizations of the prepared formulations by different instrumental techniques including FTIR spectroscopy, Differential scanning calorimetry (DSC) and Powder X-ray diffraction (PXRD).
3. Results of the dissolution studies and drug release.
4. Cytotoxicity study to determine the anticancer effect of the drug and formulation.
5. Characterization of powdered mixture and dissolution study and quality control tests performed on the oral disintegrating tablets formed.