الفهرس 
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Abstract
Warts are cutaneous infections caused by HPV. Many observations have suggested that wart proliferation is controlled by the immune system, particularly the cell-mediated immunity. The role of immunity in warts was evidenced by increased prevalence and persistence of warts in immunosuppressed populations, while spontaneous regression of the majority of warts was associated with enhanced cellular immunity (Marei et al., 2021). Intralesional antigen immunotherapy has been successfully used in the treatment of warts with the potential advantages of good efficacy, high safety profile, low recurrence rate, and clearance of untreated distant warts. Intralesional immunotherapeutic antigens include mumps, Candida, Trichophyton, tuberculin, BCG vaccine, zinc sulfateand MMR vaccine (Marei et al., 2020) This study compare the safety and efficacy of intraleisional Candidal antigen versus Intralesional 2% Zinc sulphate for treatment of cutaneous warts. Our studyincluded105 patients having different types of cutaneous warts (common, plantar and plane) in all treatment groups It included 51 male patients and 54 female patients, their ages ranged from (4-49 years) old. They were randomly assigned into 3 treatment groups 35 patient in each group. group (1) treated with IL injection of Candidal antigen 1/100 concentration. group (2) treated with IL injection of Candida antigen 1/1000 concentrations. group (3) treated with IL injection of 2% Zinc sulphate. Our results revealed that: Regarding the number of injected warts in different wart types (common, plantar and plane), there was decrease in their number in all groups after treatment. and it was significant decrease in G1 and G2.