Search In this Thesis
   Search In this Thesis  
العنوان
Haploidentical versus matched sibling donor stem cell transplant in adult acute myeloid leukemia patients /
المؤلف
El-Dsouky, Mohamed Abdel-Wahab Mohamed.
هيئة الاعداد
باحث / محمد عبدالوهاب محمد الدسوقي
مشرف / محمد علي البيومي
مشرف / رأفت محمد عبدالفتاح
مشرف / شريف رفعت علي
مناقش / توفيق رجب الخضري
مناقش / محمد محمود مرسي
الموضوع
Leukemia, Myeloid, Acute - Genetics. Acute myeloid leukemia. Leukemia, Myeloid, Acute - Therapy.
تاريخ النشر
2021.
عدد الصفحات
97 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الطب الباطني
تاريخ الإجازة
1/1/2021
مكان الإجازة
جامعة المنصورة - كلية الطب - قسم الباطنة العامة
الفهرس
Only 14 pages are availabe for public view

from 117

from 117

Abstract

”Acute myeloid leukemia (AML) is an uncontrolled clonal proliferation of myeloid precursors resulting in collection of leukemic blasts within bone marrow (BM), peripheral blood and other tissues.AML is rapidly lethal if untreated. With intensive treatment, 60 to 80 % of younger adults achieve a complete remission (CR).Allo-HSCT is a potentially curative therapy for AML cases. But, a human leukocyte antigen (HLA)-identical sibling is available for 25–35% of AML cases. For those who lack a full matched sibling donor (MSD), other stem cell sources are available including an unrelated donor, or a HLA-mismatched family donor (Haplo).The aim of work: Detection Different transplant related toxicity and Comparing outcome of matched sibling donor versus haplo-identical as regard leukemia free survival (LFS) and overall survival (OS) Research Plan: This retrospective study was conducted on 40 patients adult AML (non-APL) 50% of them underwent BMT from matched doner and 50% from haploidentical donor recruited from Naser cancer institute, Air Force specialized hospital in period from May 2016 to May 2021 and patients received chemotherapy at Oncology center Mansoura University then referred for BMT.