الفهرس 
Disorders of the thyroid glandOnly 14 pages are availabe for public view
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Abstract
Sepsis is an emergency event that often found in pediatric
intensive care unit. Over five decades with antibiotic use and optimal
supportive care, mortality caused by sepsis in child still high. It is a
common cause of death in infants and children. The incidence of
severe sepsis and septic shock has risen in the past 30 to 40 years.
Hemodynamic disturbances occur in sepsis, such as
cardiovascular and hormonal balance disorders. Hormonal changes
that frequently occur in sepsis are often from the thyroid, in the form
of euthyroid sick syndrome (ESS) or non-thyroidal illness syndrome
(NTIS).
These syndromes are characterized by decreased levels of
thyroid hormones, but without the impaired function of the thyroid
hormone that occurs in non-thyroidal severe systemic disease.
Changes in thyroid hormone eventually lead to impaired oxygen
consumption and hematopoiesis, as well as cardiovascular,
sympathetic nervous, respiratory, and digestive system problems,
which ultimately lead to organ system failure and death.
Therefore, thyroid hormone is also an important predictor in the
mortality in patients with sepsis. The magnitude of the thyroid
function test result abnormalities seems to depend on the severity and
duration of illness, rather than the type of ill.
We aimed at assessing the prevalence of non-thyroidal illness
syndrome among children with sepsis and the value of NTIS for
prediction of clinical outcome among these children.