الفهرس 
Capsule EndoscopyOnly 14 pages are availabe for public view
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Abstract
”Background: Colorectal cancer has a complicated etiology, comprising a combination of environmental and genetic factors. P53 mutations are the most common genetic events in human malignancies, accounting for more than half of all cases. In roughly 45–83 percent of colorectal carcinomas, elevated Alpha-methyl acyl-CoA racemase (AMACR) protein levels can also be observed. Objectives: the current study aimed to evaluate the expression of Alpha - Methylacyl - Coenzyme A Racemase (AMACR) versus P53 and its correlation with staging and grading of colorectal neoplasia. Methods: Over the course of a year, 50 instances of colorectal neoplasia were assessed at Mansoura university hospitals. Routine laboratory tests, tumor markers, radiographic studies, and immunohistochemistry for AMACR and P53 were performed on all of the patients. Results: 78 % of the studied cases were negative for P53, 16% +3(strong expression), 4% +2 (moderate expression) & 2% +1(poor expression). AMACAR was distributed among studied cases as follows; 54% negative, 26%+1, 14% +2 & 6% +3. There was a statistically significant association between histology and AMACAR expression was found with 91.3% of the cases with AMACAR positive had moderately differentiated adenocarcinoma and 8.7% of the cases with positive AMACAR was well differentiated adenocarcinoma (P=0.04) while there was a statistically significant association detected between P53 positivity and laboratory findings. Conclusion: In cases of both moderately and well differentiated adenocarcinoma, AMACAR expression exhibited a substantial association with histological findings, whereas P53 expression showed no significant association with histopathological findings.”