الفهرس | Only 14 pages are availabe for public view |
Abstract Background: Warts constitute the commonest cutaneous manifestation of human papilloma virus (HPV) infection. A variety of procedures has been used and treatment may be invasive and/or conservative. In this study we compared the efficacy and safety of intralesional Candida antigen injection and contact diphencyclopropenone (DPCP) in the treatment of common warts. Methods: Fourty patients with common warts were randomly divided into two groups. One group received intralesional injection of candida antigen repeated every 3 weeks until complete improvement of all warts or for a maximum of three sessions. The second group was treated weekly by contact DPCP for a maximum of five sessions or until clearance of all lesions. T-test and chi-square test were used for statistical analysis, and P < 0.05 was considered statistically significant. Results: The patients showed better therapeutic response to intralesional candida vaccine than contact DPCP but it was not significant (p value=0.139). Our findings showed that candida antigen was effective with response rate 81.25 %, where 60% of patients showed complete clearance of central treated wart, while 18.1% of patients showed clearance of adjacent warts. On the other hand, DPCP was shown to be also effective in treatment of warts with a response rate of 50%, where 25% of patients showed complete clearance of central treated wart, but no clearance of adjacent warts. 40% of patients in the candida antigen group suffered side effects of treatment in comparison to 100% of patients in the DPCP group and this difference was statistically significant (p value= 0.002). For the candida antigen group, treatment failure was significantly higher among patients with longer wart duration (p value = 0.022), which was not observed in the DPCP group. |