الفهرس | Only 14 pages are availabe for public view |
Abstract Breast cancer is the most common of cancer death among women worldwide Radiotherapy has consistently remained one of the two most effective treatments for cancer. The objective of radiation oncology is to increase the local cure rates of tumor, which typically depend on the delivered dose. The dose distribution, in the tumor or organ at risks, is calculated by specific dose calculation algorithms. Based on the predicted dose distribution, radiobiological models are able to estimate the (TCP). These models are multiple and based on different mathematical and statistical concepts. Some of them are directly available in the treatment planning systems (TPS), which are used to calculate the dose distribution. Based on the predicted dose distribution, radiobiological models are able to estimate the TCP. These models are multiple and based on different mathematical and statistical concepts which are used to calculate the dose distribution. However; several precautions should be observed for a safe use of these TCP models to predict radiotherapy outcomes. This study is aimed to evaluate the dosimetric differences in treatment plans with different number of beams on 3D conformal radiotherapy as well as evaluation the biologic differences in treatment plans with different number of beams on 3D conformal radiotherapy. The effect of the number of beams were compared biologically and dosimetrically for two radiotherapy plans using Niemierko model for NTCP calculation and for TCP calculation also in the ranking of different treatment plans for breast cancer patients via analysis the DVH for the two plans. The NTCP and TCP were calculated by using MATLAP program that will be used to calculate them for any plan. |