الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
 |  | from | 74 |  |  |
| | | from | 74 | | |
Abstract
Hand Osteoarthritis (HOA) is one of the main degenerative joint diseases. Pain andreducedfunction are the main symptom in HOA. Previously HOA was taken into considerationas a natural degenerative disease, however this idea had been modified and cutting-edge studies has validated thatinflammation is one of the key elements resulting in the cartilage destruction.Cytokines, as Interleukin-1β (IL-1β), induce expression and production of proteolytic enzymes such as matrix metalloproteinases (MMPs) and aggrecanases. Chondrocyte-derived MMPs are the primaryenzymes concerned withthe breakdown of cartilage collagens and proteoglycans.Research within the area of HOA is critical to assist early prognosis, haltthe development of the disease, and preventing disability. The goal of the study became to evaluate the relation of serum degree of IL-1β and MMP-13 with primary HOA severity and functional impairment.
The study was performed on 30 patients diagnosed with HOA, fulfilling the ACR 1990 criteria for diagnosis of HOA and 20 normal volunteers. Demographic data and anthropometric measurements had been recorded for all participants. Clinical characteristics of the disease including duration of disease, pattern of joint involvement, pain and disease severity in addition tofunctional impairment of HOA had been assessed. Radiographic severity of HOA was evaluatedby using Kellegren and Lawerence (KL) score. Serum IL-1β and MMP-13 had been assessed by the use of double-antibody sandwich ELISA approach in all participants.
This study included 30 female HOA patients with an mean age of 61.6 ±2.79 years and a mean BMI of 31.3 ± 5.14 kg/m2. It additionally involved 20 healthy females with an mean age of 60.35±2.91 years and an mean BMI of 28.57 ± 4 kg/m2.There was no statistical importance difference between the two groups as regards demographic data and anthropometric measurements (p >0.05). Although the patients had a weaker median hand grip and pinch power of the dominant hand, it did notreach statistical significance.
The mean duration of HOA was3.57±1.14 years. The majority of patients (56.6%) had generalized OA. The were the DIP and PIP joints were most typically involved joints (78.3 and 46.6% respectively). All patients had mild to moderatepain. The median combined deformity and pain index was eight ranging from four to twelve. All patients had mild to moderatefunctional impairment as assessed using the FIHOA questionnaire. The KL totalscore was between twelve and seventy eight with a median of thirty eight, displaying that all patients had mild to moderate radiographic HOA.
The median IL-1β was 20.1 pg/ml ranging from 16.8-49.6 pg/ml for patients and 17.24 pg/ml ranging from 14.3-26.1 pg/ml for control. While, the median MMP-13 was 6.85 pg/ml ranging from 5.8-19.5 pg/ml for patients and 6.05 pg/ml ranging from 5.4-6.8 pg/ml for control. Although IL-1β and MMP-13 had been higher in patients than controls, it did not attain statistical significance (U=204, P=0.057 and U=179, P=0.073) respectively.
Interleukin-1β confirmed statistical correlation only with pinch power of the dominant hand. Both assays confirmed insignificant correlation with the different severity or functional evaluation measures.
These findings suggest that IL-1β and MMP-13 appear to have an insignificantrole in detection of severity and functional impairment in mild to moderate HOA.