الفهرس 
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Abstract
Infertility means the failure to achieve a clinical pregnancy after 12 months of regular unprotected sexual intercourse; it affects approximately 15% of couples. The male factor is the main cause of infertility in 20% of cases and contributes in about 50%. There are many etiologies for male factor infertility; Infectious processes contribute to about 15% of such cases. Male genital tract infections are difficult to detect as they are asymptomatic in many cases. A number of patients seeking treatment for impaired fertility are increasing so the diagnosis of “silent” genital tract infections should receive attention as the infection may be linked to asthenozoospermia. Infections are potentially treatable causes of male infertility, but the resistance to common antibiotics and the poor compliance may impede the efficacy of antibiotics in resolving complicated GTI or restoring fertility. Citric acid has antioxidant and anti-inflammatory functions in tissues damaged by environmental factors; also it favors the synthesis of glycosaminoglycans in various tissues. Citric acid levels are regulated by testosterone, and like fructose can be observed elevated in oligozoospermic and azoospermic subjects without a convincing clinical explanation. The aim of the present study is to evaluate effect of genital tract infection on level of citric acid in semen of infertile men. This studywas carried out on 30 infertile male patients. Patients were recruited from the outpatient clinic of Andrology unit in Dermatology and Andrology& STDs Dep., Mansoura University Hospital for one year. Informed written consents were obtained from all participants in this study. unmarried, moderate to severe varicocele, cigarette smoking and drug abuser, patients had taken antimicrobial 3 months ago were excluded. Collection of semen samples from infertile male patients by masturbation after 2 to 5 days of abstinence. Before sampling, the patients were advised to urinate and then wash their glans penis with regular soap and water then dry it with clean towel. Also, the patients will be carefully instructed to avoid contamination of inner jar by fingers or the penis. Semen analysis was done with computer assisted semen analysis (CASA). After detection of pyospermia by perioxidase stain, citric acid was measured in semen using citric acid test. The results showed that, the mean age (in years) of the studied group was 29.57 with SD of 4.22. themean±SD citric acid was significantly increased after receiving antibiotic 16.64±2.24 versus before treatment 3.32±1.40. It was concluded that, citric acid was significantly increased after receiving antibiotic versus before male genital infection treatment.