الفهرس 
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Abstract
Periodontitis is known as a chronic inflammation of the soft tissue surrounding and supporting the teeth, which causes periodontal structural damage, alveolar bone resorption, intrabony defects formation.
Regeneration of lost periodontium is the ideal treatment approach. A variety of treatment modalities have been developed such as surgical techniques in the form of OFD alone or accompanied with the addition of adjunctive pharmacological agents like SMV.
SMV, has been widely used in clinical practices to control cholesterol levels. Besides its lipid-lowering function, this statin is notable for other pronounced effects; pleotrophic effects including anti-inflammatory, immunomodulatory, and antioxidant properties, in addition to the promotion of angiogenesis, osteoclastgenesis inhibition and increased differentiation of osteoblasts, leading to bone formation. These properties provide great potential for SMV to be used as a host modulatory and a regenerative agent in periodontal therapy.
The present study was conducted to evaluate the effectiveness of 1.2% SMV gel in the management of intrabony defects in periodontitis, on clinical parameters and alveolar bone changes using direct digital radiography.
Fourteen patients of both sexes and ages ranging from 25-55 years were selected in this study. Patients were diagnosed as having stage III periodontitis with at least two contralateral angular intrabony defects in asplit mouth design were randomly assigned with OFD only for one side while the other side was treated by OFD plus SMV gel. Clinical parameters including modified sulcular bleeding index, plaque index, probing pocket depth and clinical attachment level were recorded before surgery and throughout the study period. Radiographic linear and denistometric measurements were performed at baseline, three and six months following surgery.
Our study showed that there was an improvement in the clinical parameters by time from baseline to 6 months. Regarding the radiographic parameters, Alveolar bone level (ABL) improved in both groups. On the other hand bone density increased from baseline to 6 months in SMV group, while in OFD group bone density decreased at 3 months then increased at 6 months.
The result demonstrated the greater improvement of clinical and radiographic parameters in SMV group than OFD group, however, the difference was statistically insignificant.