الفهرس | Only 14 pages are availabe for public view |
Abstract Intrahepatic cholestasis with pregnancy (ICP) is one of the pregnancy related hepatic disorders that can result in wide range of perinatal morbidity. The severity and risk of these adverse perinatal outcomes are directly associated with the maternal total serum bile acids (TSBA) level. The pathogenesis of fetal distress in ICP is not well understood. However, the literature has introduced multiple theories, for these perinatal adverse events, which are all related to the severity of hypercholanemia during pregnancy and effects of toxic bile acids on placental blood vessels and fetal heart. Asymptomatic hypercholanemia of pregnancy (AHP) has recently become an issue in obstetrics field. It is characterized by elevation in serum bile acids level in pregnant women in the absence of any symptoms or biochemical markers of ICP or any other hepatobiliary disease. The prevalence of AHP usually increases with gestational age. It has been reported that it affects about 10% of pregnant women. The objective of our work was to study the maternal total serum bile acids (TSBA) level in cases of meconium stained amniotic liquor in asymptomatic patients havin |