الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Management of alveolar ridge defects is considered one of the most challenging tasks in periodontal regenerative field. Although, many surgical approaches have been proposed for correction of ridge atrophies, (such as GBR, onlay grafts and distraction osteogenesis), the gold standard technique is the use of autogenous bone grafts. To minimize the host morbidities and other post-operative complications associated with autografts, the use of alternative tissue engineered bone constructs has emerged. Drynaria fortunei is considered one of the frequently used Chinese herbs in the area of orthopedics and bone healing with proved osteopromotive potential. Previous studies demonstrated that Df is a powerful inducer of osteogenic differentiation of BMSCs. Therefore, it seemed reasonable to use this naturally occurring herb in tissue engineering approach instead of the expensive biological mediators and growth factors that have low half-life and may show a relative degree of protein instability. The aim of this experimental study was to assess the adjunctive use of Df extract with BMSCs in the management of horizontal alveolar ridge defects in a canine model. This assessment was carried out histologically and histomorphometrically. Furthermore, assessment of the osteogenic potential of Df extract on the proliferation of BMSCs was carried out histomorphometrically.