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العنوان
Study of the role of the tyrosine kinase receptors ErbBs in the signal transduction and migration of CNS neurons and PNS glial cells in response to neuregulin 1 alpha and beta =
المؤلف
El Soury, Marwa Mohamed Emad El Din.
هيئة الاعداد
مشرف / Marwa Mohamed Emad El Din El Soury
مشرف / Isabelle Perroteau
مشرف / Giovanna Gambarotta
مشرف / Ismail Sabry
الموضوع
tyrosine kinase. neuregulin.
تاريخ النشر
2014.
عدد الصفحات
79 p. :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
الكيمياء الحيوية ، علم الوراثة والبيولوجيا الجزيئية
تاريخ الإجازة
9/6/2014
مكان الإجازة
جامعة الاسكندريه - كلية العلوم - Biochemistry
الفهرس
Only 14 pages are availabe for public view

from 97

from 97

Abstract

ErbB receptors belong to the family of receptor tyrosine kinases. The ErbB family is composed of four members: ErbB1 (also known as EGFR), ErbB2, ErbB3 and ErbB4. Different ErbB4 isoforms are present and can be classified according to their ability to be cleaved by membrane metalloproteases (JMa) or not (JMb), whether they can bind to PI3K and E3 ubiquitin ligase (cyt1) or not (cyt2), thus forming four isoforms: JMa-cyt1, JMa-cyt2, JMb-cyt1 and JMb-cyt2 that differ from each other both structurally and functionally.