الفهرس 
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Abstract
Background: Sulpiride (SUL), is a selective antidopaminergic drug that had extensive
biological activities. However, its sparingly aqueous solubility and limited gastrointestinal
permeability lead to scanty oral bioavailability which hinders its clinical efficacy.
Objective: SUL-loaded lipospheres (SUL-LPS) were designed to serve as an oral biocompatible
nanovector for improving SUL permeability as well as conquering its low oral
absorption and then in turn enhancing its antidepressant action.
Methods: SUL-LPS were fabricated via two processing techniques namely, melt emulsification
and solvent evaporation. The impact of different lipid cores, phospholipid shells
together with various surfactant concentrations and types on the lipospheres properties
were screened. Detailed physicochemical elucidations were performed followed by ex vivo
permeation appraisal using the non-everted intestine model. The pharmacokinetic parameters
of SUL-LPS, free SUL and marketed product were assessed following oral administration to
healthy rats. Reserpine-induced depression rat model was used to assess the antidepressant
action of SUL-LPS on which full behavioural and biochemical analysis was conducted.
Safety attributes of nanoencapsulated SUL on the brain and other internal organs were
evaluated.