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العنوان
Synthesis and comparative effect of some new organic compounds on enzymes =
المؤلف
Ismail, Olfat Samir Nassar.
هيئة الاعداد
مشرف / Olfat Samir Nassar Ismail
مشرف / Galila Ahmed Yacout
مشرف / Nihal Mohammed Naguib El Guindy
مشرف / Nihal Mohammed Naguib El Guindy
الموضوع
organic compounds. enzymes.
تاريخ النشر
2015.
عدد الصفحات
113 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الكيمياء الحيوية ، علم الوراثة والبيولوجيا الجزيئية
تاريخ الإجازة
9/6/2015
مكان الإجازة
جامعة الاسكندريه - كلية العلوم - Biochemistry
الفهرس
Only 14 pages are availabe for public view

from 130

from 130

Abstract

There are some compounds that have an aldehyde group (forming Schiff base) or phenyl group and have the ability to effect on the activity of some enzymes. In our study we designed a new six synthetic compounds that have aldehyde or phenyl groups and evaluate their effects on 2 important enzymes :( tyrosinase and monoamine oxidase). Tyrosinase is monophenol monoxygenase (E.C. 1.14.18.1).It is widely distributed in microorganisms, plants and animals .This enzyme catalyzes the first two steps in mammalian melanogenesis as the rate limiting step enzyme in melanin biosynthetic pathway. Any defects in this enzyme may cause many diseases as hyperpigmentation, vitiligo, cancer and other diseases.