الفهرس 
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Abstract
Diabetic nephropathy is a syndrome of albuminuria, decreasing glomerular filtration rate (GFR), arterial hypertension, and increased risk of cardiovascular disorders.Diabetic nephropathy affects 20-40% of diabetic patients, including type 1 (insulin-dependent) and type 2 (non-insulin-dependent). Aim of study: assess the role of omentin 1 and IL6 as one of pro inflammatory cytokines in patients with diabetic nephropathy. Subjects and methods: It is a case control study conducted on patients with diabetic nephropathy and control. Subjects were divided into 3 groups. group A (controls) included 30 healthy patients .group B (cases) included 38 already diagnosed diabetic nephropathy patients and were divided into 2 subgroups : diabetic nephropathy with microalbuminuria and diabetic nephropathy with macroalbuminuria. group C included 20 diabetic patients without nephropathy Inclusion criteria:-Diabetic patients with diabetic nephropathy and diabetic patients without DN Exclusion criteria :- The following will be excluded : autoimmune diseases, pregnancy, malignancy and cardiac diseases Serum samples separated and examined for fasting blood glucose, creatinine, cholesterol, triglycerides and insulin, omentin 1 and IL6 by ELISA technique. Results: Significantly lower omentin 1 in DN group when compared to control and DM without DN groups (p<0.001 for both). Significantly higher IL6 in DN group when compared to control and DM without DN groups (p<0.001 for both). Conclusion : Lower omentin and higher IL6 were associated with DN. Omentin showed significant negative correlation with creatinine, DN, albuminuria, IL6. While, IL6 showed significant positive correlation with creatinine, DN, lbuminuria and negative correlation with omentin. Higher creatinine, IL6, lower omentin were considered independent predictors for DN occurrence and severity.