الفهرس 
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Abstract
ABSTRACT : The present thesis deals with preparation of bichalcophene and furanylnicotinamidine derivatives and blending them with sodium carboxymethyl cellulose as a carrier matrix. The obtained films were characterized FTIR spectroscopy and thermal gravimetric analysis (TGA) followed by the application for controlled release study. FT-IR spectra shows the characteristic peaks of bichalcophene which are shifted in case of CMC-bichalcophenes blends indicating the possible hydrogen bonding between –OH and/or C=O groups of CMC and –NH2 groups and /or N-atom of pyridine ring of bichalcophenes. TGA shows that addition of bichalcophenes to CMC polymer triggers its degradation indicating the relative weakness of intermolecular new H-bonding between CMC and bichalcophenes compared to the intramolecular H-bonding within CMC matrix. Bithiophene derivative shows initial increase in the release rate in the first 4 h, then gradually decreased. These findings have been discussed based on inter- and intra-molecular H-bonding between CMC and the drug compounds. Bifuran derivatives behave differently from that for bithiophene derivatives and discussed based on the difference in the chemical structure and their solubility in the dissolution medium. Drug release of 6-(5-Phenylfuran-2-yl) nicotinamidine (4F), 6-[5-(4-Methoxyphenyl)furan-2-yl]nicotinamidine (5F) and 6-[5-(3,5-Dimethoxyphenyl)furan-2-yl]nicotinamidine (6F) have been studied and discussed in the light of their chemical structure. Drug release of 6-[5-(3-Chloro-4-methoxyphenyl)furan-2-yl]nicotinonitrile (7C) and 6-[5-(3-Chloro-4-methoxyphenyl)furan-2-yl]nicotinamidine (8F) have been investigated and also discussed based on the their chemical structure and ability to H-bonding and physical crosslinking that may result in release change either retardation or acceleration.