الفهرس 
TTP and HUSOnly 14 pages are availabe for public view
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Abstract
Background: Thrombotic microangiopathy with pregnancy can lead to maternal and fetal life threatening adverse outcome.
Aim of the Work: to study the demographics (age, parity,…. ), risk factors, treatment modalities and outcome of pregnant females with thrombotic microangiopathy in Ain Shams University Maternity Hospital in 5 years.
Patients and Methods: This study was conducted at Ain Shams University Maternity hospital retrospectively on 419 patients, the study population were pregnant women presented to the hospital from January 2014 to December 2018, with pregnancy associated thrombotic microangiopahty. The study was performed through revising the medical records in the archive and the ICU and contacting the patients to assess demographic data, risk factors, presentation of the patient, type of the syndrome and finally the maternal and fetal outcome.
Results: HELLP syndrome was the most common type. Majority of the cases were delivered by Cesarean section (72.1%). CHTN, AKI, CKI, maternal mortality were significantly most frequent in HUS. Maternal mortality was 8.8 % and neonatal mortality was 26.7%. Majority of the cases were admitted in ICU (87.1%). maternal mortality were significantly most frequent in HUS.
Conclusion: TMAs in pregnancy continues to pose a large challenge to the obstetrician, immunologist and nephrologist due to potential risks and complications. Pregnancy outcome is definitely more optimistic when termination of pregnancy occurs early in the disease with the possible use of coticosteroids with or without plasma exchange transfusion in contact of a multidisciplinary approach team