الفهرس 
Aim of the WorkOnly 14 pages are availabe for public view
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Abstract
Schizophrenia is a complex, chronic mental health disorder characterized by an array of symptoms, including delusions, hallucinations, disorganized speech or behavior, and impaired cognitive ability. The early onset of the disease, along with its chronic course, make it a disabling disorder for many patients and their families. Aim of the Work: The purpose of our study is to evaluate the potential role of SLC22A and HMOX-1 genes in prediction of response to second generation antipsychotic agents
Patients and Methods: This study is prospective cohort study, was conducted sixty patients with schizophrenia underwent testing with OCR for both SLC22A and HMOX-1 genes. They were divided into 2 groups, group (A) received olanzapine and group (B) received resperidone and followed up for 6 weeks then response was assessed for response.
Results: there was highly statistically significant positive correlation between treatment resistance and high gene expression of HMOX-1 gene, and statistically significant negative correlation between treatment resistance and high expression of SLC22A gene
Conclusion: HMOX-1 and SLC22A are good predictors for response to second generation antipsychotic agents.