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Abstract Summary and Concluosion Onychomycosis is a fungal infection occurring in the nails. Typically, it manifests as discoloration of the nail, nail plate thickening, subungual hyperkeratosis and onycholysis. It can affect fingernails or toenails and may involve various components of the nail. Onychomycosis is caused by dermatophytes, non-dermatophyte molds and yeasts. Although dermatophytic pathogens are normally susceptible to antifungal agents, it is estimated that only 25–50% of patients with onychomycosis are cured after the standard treatment. There are four major clinical presentations of onychomycosis, most of which can be further subdivided. The four major types are: DLSO, PSO, SWO, and TDO. Distal subungal infections can be further subdivided into distal lateral subungal onychomycosis and endonyx subungal onychomycosis. Onychomycosis can have significant negative effects on patients’ emotional, social, and occupational functioning. Affected patients may experience embarrassment in social and work situations, where they feel unclean, unwilling to allow their hands or feet to be seen. Patients may fear that they will transmit their infection to family members, friends, or coworkers, fears that can lead to diminished selfesteem and the avoidance of close relationships and reduced quality of life. Treatment options include systemic and topical antifungal agents, palliative care, mechanical or chemical debridement, laser and various combinations of these modalities |